TV LAVIN: Ivermectin: A Multifaceted Drug?

Sunday, September 14, 2025

Ivermectin: A Multifaceted Drug?

1. Origin and History

Ivermectin was discovered in the 1970s by Satoshi Ōmura and William Campbell as part of the avermectin derivatives, initially intended for veterinary use. Later, it was approved for humans in 1987–1988 under names like Mectizan. (pmc.ncbi.nlm.nih.gov)

2. Approved Human Uses – Antiparasitics

In humans, ivermectin is approved for several parasitic infections, including:

Onchocerciasis (“river blindness”).
Strongyloidiasis.
Others such as filariasis, ascariasis, trichuriasis, cutaneous larva migrans, gnathostomiasis, scabies, and lice. (pmc.ncbi.nlm.nih.gov)

It is also approved for topical use in dermatological conditions such as rosacea, reducing inflammation and Demodex mites. (pmc.ncbi.nlm.nih.gov)

3. Studies on COVID-19

Interest in ivermectin as a potential COVID-19 treatment surged, but results were mostly negative or inconclusive:

In vitro tests showed that ivermectin inhibited SARS-CoV-2 replication within 48 hours. (sciencedirect.com)
However, human clinical trials:
- A large NEJM trial concluded ivermectin did not reduce hospitalizations in mild cases. (nejm.org)
- The Malaysian I-TECH study found ivermectin did not prevent disease progression in high-risk patients with mild to moderate COVID. (jamanetwork.com)
- A meta-analysis concluded there is no solid evidence of mortality reduction or clinical benefit. (pmc.ncbi.nlm.nih.gov)

Authorities such as the FDA, WHO, and EMA do not recommend ivermectin for COVID-19 treatment or prevention, except within clinical trials. (fda.gov)

4. Potential Use in Cancer

Several preclinical studies (cells, animals) explored ivermectin as an anticancer drug:

Reviews show ivermectin may inhibit tumor proliferation, metastasis, and angiogenesis. (pmc.ncbi.nlm.nih.gov)
Colorectal cancer: induced apoptosis via ROS, Bcl-2/Bax pathways. (frontiersin.org)
Liver cancer: synergistic effect with sorafenib. (bpspubs.onlinelibrary.wiley.com)
Ovarian cancer: enhanced effects when combined with pitavastatin. (mdpi.com)
Proposed mechanisms: apoptosis, autophagy activation, stem cell suppression, immune modulation. (integrative-cancer-care.org)

⚠️ But these are preclinical findings—clinical trials in humans are still lacking.

5. Commercial Brands and Formulations

For humans:

Stromectol® (oral tablets).
Mectizan® (widely used in public health donation programs).
Sklice® (lotion for lice).
Soolantra® (topical cream for rosacea). (en.wikipedia.org)

For animals:

Ivomec® (Merial, cattle/horses).
Oral pastes for horses: Bimectin, DuraMectin, Intermectin Paste, IverQuest.
Other equine/veterinary combinations with praziquantel.

6. Why Human vs. Animal Versions Differ

Dosage/strength – veterinary formulations are made for animals weighing 400–600 kg.
Excipients – inactive ingredients in animal products are not tested for human safety.
Regulation – human medicines pass through strict FDA/EMA trials, animal ones do not.
Toxicity risks – overdoses can cause neurological damage (seizures, coma, low blood pressure).

7. Comparative Evidence

Indication / Use	Evidence Level	Human Approved?	Current Recommendation
Parasitic infections	High (onchocerciasis, strongyloides, etc.)	Yes	Approved use
Scabies, lice, rosacea	High (clinical trials)	Yes	Approved use
COVID-19	Low/inconclusive	No	Not recommended
Cancer (preclinical)	Experimental	No	Research only

8. Rumors vs. Reality

Rumor: horse paste ivermectin cures COVID or “cleanses parasites” in humans.
- Reality: risky because of toxic excipients and excessive dosing.
Rumor: ivermectin is a “hidden cure” for cancer/COVID.
- Reality: clinical trials so far don’t support this. Authorities discourage self-medication.

Conclusion

Ivermectin is a powerful antiparasitic drug with proven benefits in tropical diseases and dermatological conditions. It has a remarkable humanitarian history through mass-donation programs. However, its use for COVID-19 or cancer remains unproven in humans. Veterinary formulations are not safe substitutes for human prescriptions.

#invermectin

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Origins of the surname Lavin

The surname Lavin holds deep historical roots, with connections to several regions and noble families throughout Europe. The name likely stems from ancient Latin or Old Spanish origins, where it may have evolved from the name Levinus or the Latin word Lavare (to wash or cleanse). There are also theories that the Lavin surname has ties to the Levitical priesthood in ancient Israel, possibly connected to the tribe of Levi, the priestly caste of the Hebrew people. This theory holds special significance for families tracing Jewish ancestry that later converted or adopted Christian surnames. Heraldic Symbols and Coat of Arms: One of the most compelling aspects of the Lavin surname is its association with heraldic symbols. Heraldry was used in medieval times to identify families of noble standing, and the Lavin family is no exception. Coat of Arms Description: The Lavin coat of arms typically features a shield with blue and silver elements, symbolizing loyalty and purity, respectively. These colors are often accompanied by a lion rampant, representing courage and strength, a common motif in noble families' coats of arms. Symbolism: The lion on the Lavin coat of arms could be interpreted as a symbol of royalty and bravery, indicating that members of the Lavin family may have been involved in military or royal service in medieval times. The shield's colors might also suggest the family's loyalty to the crown or religious figures during significant historical events. The surname Lavin has roots in both Irish and French origins, with a few other variations depending on the region. 1-Irish Origin: The Lavin surname is most commonly associated with Ireland, particularly from County Roscommon. It is an Anglicized form of the Gaelic name Ó Láimhín, which means "descendant of the son of the prince." This surname is historically linked to Irish nobility, and its origins can be traced back to the early Gaelic kingdoms. 2-French Origin: The name Lavin may also have French roots, particularly as an occupational name derived from the French term "La Vigne," meaning "the vineyard." This would suggest that the name was originally given to people who owned or worked in vineyards, particularly in regions like Gironde and Loire. Some of these French Lavins were Huguenots who fled to England during the religious persecutions of the 17th century. 3-Other Origins: In Cornwall, England, Lavin might be linked to an Anglo-Norman personal name. Additionally, in Spain, the surname Lavín is a habitational name from the Cantabria region. The Lavin surname has appeared in various records across the United States, the UK, and other countries, often linked to significant historical migrations, such as the Irish Potato Famine